References

Patents and Discoveries (and/or filed with NIH Edison):

1. Use of recombinant human keratinocyte growth factor (rHuKGF) to prevent intestinal atrophy during the administration of total parenteral nutrition.  With Hua Yang. Discovery filed with NIH Edison 2003.

2. Use of angiotensin converting enzyme inhibitor to Prevent Intestinal Epithelial Apoptosis.  With Barbara Wildhaber. Discovery filed with NIH Edison 2003.  Patent filed March, 2004.  U.S. Patent updated with Hua Yang and Barbara Wildhaber, to include Class: 514423000 (USPTO), A61K031/401 (Intl Class). 

3.  Use of a new compound Enalaprilat combined with polyethylene glycol 1000/1500 delivered as an enema for the treatment of ulcerative colitis, proctitis and pouchitis.  With Barbara Wildhaber. Discovery filed with NIH Edison 2003.  U.S. Patent filed December, 2005.

4. Use of interleukin-7 to prevent total parenteral nutrition-associated changes to the intestinal immune system.  With Hua Yang. Discovery filed with NIH Edison 2004.

5. Mechanical Extension Implants for Short Bowel Syndrome.  With Diann Brei, Jonathan Luntz, and Ariel Spencer.  NIH Edison Discovery filed September, 2005.  First filing with USPTO: February, 2007.

 

Publications by the Teitelbaum Laboratory

Clinical
Hirschsprung

van Leeuwen, K, Teitelbaum, DH, Elhalaby, EA, Coran, AG:  The long-term follow-up of redo-pullthrough procedures for Hirschsprung’s disease.  J Pediatr Surg 35(6):829-834, 2000.

Teitelbaum, DH, Cilley, R, Sherman, NJ, Bliss, D, Uitvlugt, ND, Renaud, EJ, Kiristioglu, I, Bengstom, T, Coran, AG: A decade experience with the primary pull-through for Hirschsprung’s disease in the newborn period: A multi-center analysis of outcomes.  Ann Surg 232(3):372-380, 2000.

Coran, AG, Teitelbaum, DH: Recent advances in the management of Hirschsprung’s disease.  Am J Surg 180:382-387, 2000.

El-Sawaf, MI, Drongowski, RA, Chamberlain, JN, Coran, AG, Teitelbaum, DH: Are the long-term results of the transanal pullthrough equal to those of the transabdominal pullthrough? A comparison of two approaches for Hirschsprung disease.  J Pediatr Surg 2007, 42:41-47.

Elhalaby, EA, Teitelbaum, DH, Coran, AG, Heidelberger, KP: Enterocolitis Associated with Hirschsprung’s Disease:  A Clinical Histopathologic Correlative Study.  J Pediatr Surgery 30(7):1023-1027, 1995.

van Leeuwen, K, Geiger, JD, Coran, AG, Barnett, J, Teitelbaum, DH:  Stooling and manometric findings in Hirschsprung’s disease: Perineal vs. abdominal approaches. J Pediatr Surg 37(9):1321-1325, 2002

Wildhaber, BE, Coran, AG, Teitelbaum, DH: Total Colonic Hirschsprung's Disease: A 28-Year Experience.  J Ped Surgery 2005 40(1):203-207.

Wildhaber, BE, Pakarinen, M, Rintala, RJ, Coran, AG, Teitelbaum, DH: Posterior myotomy/myectomy to treat chronic constipation and enterocolitis in Hirschsprung’s disease.  J Ped Surg 2004, 39(6):920-6

Langer, JC, Durrant, AC, de la Torre, ML, Teitelbaum, DH, Minkes, RK, Caty, MG, Wildhaber, BE, Ortega, SJ, Hirose, S, Albanese, CT: One-stage transanal Soave pullthrough for Hirschsprung disease: A multicenter experience with 141 children.  Ann Surg 2003 238(4):569-76.

Teitelbaum, DH, Drongowski, R, Chamberlain, JN, Coran, AG: Long-term stooling patterns in infants undergoing a primary endorectal pullthrough (ERPT) for Hirschsprung’s disease.  J Pediatr Surg  32(7):1049-1053, 1997


Total Parenteral Nutrition and Cholestasis

Spencer, AU, Tracy, T, Auothmany, M, Llanos, A, Brown, MB, Yu, S, Brown, M, Shulman, RJ, Hirschl, RB, DeRusso, PA, Cox, J, Dahlgren, J, Strousse, P, Teitelbaum, DH: Neonatal Risk of Parenteral Nutrition-Associated Cholestasis: A Multivariate Analysis of the Effect of Taurine.  JPEN 2005 29(5):337-344.

Tsai, S, Strouse, PJ, Drongowski, RA, Islam, S, Teitelbaum, DH: Use of Cholecystokinin-Octapeptide to Prevent TPN-Associated Gallstone Disease.  J Ped Surgery 2005 40(1):263-267.

Teitelbaum, DH, Han-Markey, T, Shumacher, RE: Treatment of Parenteral Nutrition-Associated Cholestasis with Cholecystokinin-Octapeptide.  J Pediatr Surgery 30(7):1082-1085, 1995.

Teitelbaum, DH, Drongowski, R, Spivak, D:  Rapid Development of Hyperbilirubinemia in Infants with the Short Bowel Syndrome as a correlate to Mortality:  Possible Indication for Early Small Bowel Transplantation.  Transplant Proceedings 28 (5):2677-2678, 1996.

Teitelbaum, DH, Han-Markey, T, Drongowski, RA, Coran, AG, Bayar, B, Geiger, JD, Schork, A: Use of cholecystokinin to prevent the development of parenteral nutrition-associated cholestasis.  J Parent Enter Nutr  20(2):100-103. 1997.

Teitelbaum, DH Parenteral Nutrition-Associated Cholestasis. Current Opinion in Pediatrics  9:270-275, 1997

Teitelbaum, DH, Tracy, T, Auothmany, M, Llanos, A, Brown, MB, Yu, S, Brown, M, Shulman, RJ, Hirschl, RB, DeRusso, PA, Cox, J, Dahlgren, J, Strousse, P,:  Use of Cholecsytokinin-Octapeptide for the Prevention of Parenteral Nutrition-Associated Cholestasis.  Pediatrics 2005 115(5):1332-40.



Short Bowel Syndrome

Ehrlich, PF, Mychalischa, G, Teitelbaum, DH: The Two STEP:  An Approach to Repeating a Serial Transverse Enteroplasty. J Pediatr Surg, 2007 42(5): 819-22.

Yang, H, Teitelbaum, DH: Novel Agents in the Treatment of Intestinal Failure: Humoral Factors.  Gastroenterology 2006, 130(2S):S117-S121.

Jones, KR, Kovacevich, DS, Teitelbaum, DH: Establishing a comprehensive         database for home parenteral nutrition: Six years of data.  Nutrition in Clinical Practice  15(6): 279-286, 2000.

Teitelbaum, DH, Coran, AG: Perioperative Nutrition Support of Pediatrics.  Nutrition Support and Pediatric Surgery. Nutrition, 14(1): 130-142, 1998.

Coran, AG, Spivak, D, Teitelbaum, DH: An analysis of the morbidity and mortality of short-bowel syndrome in the pediatric age group.  Eur J Pediatr Surg 9:28-230, 1999.

Spencer, AU, Safran, J, Neeaga, A, Brown, P, Btaiche, I, Teitelbaum, DH,: Mortality and Outcomes of Pediatric Short Bowel Syndrome: Redefining Predictors of Success.  Annals of Surgery 2005, 242:403-412.


Basic Science

Total Parenteral Nutrition and the Mucosal Immune System

Yang, H, Madison, B, Gumucio, DL, Teitelbaum, DH: Overexpression of IL-7 in the Intestinal Mucosa: The role in intestinal intraepithelial lymphocyte development. Amer J Physiol Gastrointestinal and Liver Physiology 2008 (E-Pub ahed of Print, PMID: 18403617) 

Sun, X, Yang, H, Nose, K, Nose, S, Haxhija, EQ, Koga, H, Teitelbaum, DH: Decline in Intestinal Mucosal IL-10 Expression and Decreased Intestinal Barrier Function in a Mouse Model of Total Parenteral Nutrition.  Amer J Physiol  Gastrointestinal and Liver Physiology 2008, 294:139-147.

Yang, H, Haxhija, E, Sun, X, Teitelbaum, DH: Intestinal epithelial cell-derived interleukin-7: A mechanism for the alteration of intraepithelial lymphocytes in a mouse model of total parenteral nutrition.  Amer J Physiol  Gastrointestinal and Liver Physiology 2007, 292:G84-G91.

Sun, X, Spencer, AU, Yang, H, Haxhija, EQ, Teitelbaum, DH: Impact of caloric intake on parenteral nutrition-associated intestinal morphology and mucosal barrier function.  JPEN J Parenter Enteral Nutr. 2006, 30(6):474-9.

Yang, H, Finaly, R, Teitelbaum, DH:  Alteration in epithelial permeability and ion transport in a mouse model of total parenteral nutrition.  Crit Care Med 2003; 31:1118—1125.

Yang, H, Fan, Y, Finaly, R, Teitelbaum, DH: Alteration of intestinal intraepithelial lymphocytes in a mouse model of short bowel syndrome.  J Surg Res 2003; 110:276-286.

Wildhaber, BE, Yang, H, Tazuke, Y, Teitelbaum, DH: Gene alteration of intestinal intraepithelial lymphocytes with administration of total parenteral nutrition. J Ped Surg 38(6):840-843, 2003.

Wildhaber, BE, Yang, H, Teitelbaum, DH: Total parenteral nutrition-induced apoptosis in mouse intestinal epithelium:  Modulation by keratinocyte growth factor. J Surg Res 112(2):144-151, 2003.

Yang, H, Spencer, AU, Teitelbaum, DH: Interleukin-7 administration alters intestinal lymphocyte phenotype and function in vivo.  Cytokine 2005 31(6):419-28.

Kiristioglu, I, Teitelbaum, DH: Alteration of intestinal intraepithelial lymphocytes (IEL) during total parenteral nutrition (TPN).  J Surg Res 79:91-96, 1998.

Eisenbraun, MD, Mosley, RL, Teitelbaum, DH, Miller, RA: Altered development of intestinal intraepithelial lymphocytes in P-glycoprotein-deficient mice.  Development and Comparative Immunology 24 (2000):783-795.


Yang, H, Fan, Y, Teitelbaum, DH: Interferon-γ evokes epithelial cell apoptosis through a Fas/FasL interaction in a mouse model of total parenteral nutrition.  Surgical Forum, LII:9-10, 2001.

Yang, H, Wildhaber, B, Tazuke, Y, Teitelbaum, DH: Keratinocyte growth factor stimulates the recovery of epithelial structure and function in a mouse model of total parenteral nutrition.  JPEN 26(6): 333-341, 2002.

Kiristioglu, I, Antony, P., Fan, Y, Forbush, B., Mosley, RL Yang, H, Teitelbaum, DH: Total parenteral nutrition-associated changes in mouse intestinal intraepithelial lymphocytes.  Digestive Diseases & Sciences   47(5):1147-1157, 2002.

Yang, H, Kiristioglu, I, Fan, Y, Forbush, B, Bishop, DK, Antony, PA, Zhou, H, Teitelbaum, DH: Interferon-gamma expression by intraepithelial lymphocytes results in a loss of epithelial barrier function in a mouse model of total parenteral nutrition.  Annals of Surgery 236(2): 226-234, 2002.

Wildhaber, BE, Lynn, KN, Yang, H, Teitelbaum, DH: TPN-induced apoptosis in mouse intestinal epithelium: Regulation by the BCL-2 protein family. Ped Surgery Int 18: 570-575, 2002.

Wildhaber, B, Yang, H, Teitelbaum, DH: Keratinocyte growth factor (KGF) decreases total parenteral nutrition (TPN)-induced apoptosis in mouse intestinal epithelium via BCL-2. J Pediatr Surg 38(1):92-96, 2003.

Yang, H, Teitelbaum, DH: Intraepithelial lymphocyte-derived interferon-γ evokes enterocyte apoptosis with parenteral nutrition in mice.  Am J Physiol Gastrointest Liver Physiol. 284:G629-G637, 2003.

Wildhaber, BE, Yang, H, Spencer, AU, Teitelbaum, DH: Lack of enteral nutrition – effects on the intestinal immune system. J Surg Res 2005 123(1):8-16.

Wildhaber, BE, Yang, H, Coran, AG, Teitelbaum DH: Gene alteration of intestinal intraepithelial lymphocytes in response to massive small bowel resection.  Ped Surg Intern. 19(5):310-315, 2003

Yang, H, Antony, PA, Wildhaber, BE, Teitelbaum, DH: Intestinal intraepithelial lymphocyte gamma delta-T cell derived keratinocyte growth factor modulates epithelial growth in the mouse.  J Immunology 2004, 172(7): 4151-4158



Enterogenesis

Spencer, AU, Sun, X, El-Sawaf, MI, Haxhija, EQ, Yang, H, Brei, DE, Luntz, JE, Teitelbaum, DH: Enterogenesis using an implantable mechanotransduction device. Surgery 2006, 140:212-20.

Luntz, J, Brei, D, Teitelbaum, DH, Spencer, AU: Mechanical extension implants for short-bowel syndrome.  Proc Soc Photo Opt Instrum Eng. Vol. 6173, p. 69-79, Smart Structures and Materials 2006: Smart Structures and Integrated Systems; Yuji Matsuzaki; Ed. Publication.


Short Bowel Syndrome

Yang, H, Wildhaber, BE, Teitelbaum, DH: 2003 Harry M. Vars Research Award, Keratinocyte Growth Factor Improves Epithelial Function After Massive Small Bowel Resection.  JPEN, 2003, 27:198-207.

Haxhija, EQ, Yang, H, Spencer, AU, Sun, X, Teitelbaum. DH: Intestinal epithelial cell proliferation is dependent on the site of massive small bowel resection.  Ped Surg Intern 2007, 23:379-390.

Haxhija, EQ, Yang, H, Spencer, AU, Sun, X, Teitelbaum, DH: Influence of the site of small bowel resection on intestinal epithelial cell apoptosis.
Pediatr Surg Int. 2006 22(1):37-42.



Total Parenteral Nutrition and Cholestasis

Forbush, B, Kiritioglu, I, Teitelbaum, DH: Multi-drug resistance gene 2 (mdr2) expression in the murine liver: Relevance to the development of parenteral nutrition-associated cholestasis.  Surgical Forum XLIX: 569-570, 1998

Tazuke, Y, Wildhaber, BE, Yang, H, Washburn, J, Teitelbaum, DH: Total Parenteral Nutrition Leads to Alteration of Hepatocyte Cell Cycle Gene Expression and Proliferation in the Mouse.  Digestive Diseases and Sciences 2007, 52(4):920-930.

Tazuke, Y, Drongowski, RA, Btaiche, I, Coran, AG, Teitelbaum, DH: Effects of lipid administration on liver apoptotic signals in a mouse model of total parenteral nutrition. Pediatr Surg International 2004 20(4):224-228.

Tazuke, Y, Kiristioglu, I, Heidelberger, KP, Eisenbraun, MD, Teitelbaum, DH: Hepatic P-glycoprotein changes with total parenteral nutrition administration.  JPEN, 2004, 28(1): 1-7.


Angiotensin Converting Enzyme and Inflammatory Bowel Disease

Spencer, AU, Yang, H, Haxhija, EQ, Wildhaber, BE, Greenson, JK, Teitelbaum, DH: Reduced Severity of a Mouse Colitis Model With Angiotensin Converting Enzyme Inhibition" Digestive Diseases and Sciences  2007, 52(4):1060-1070.

Wildhaber, BE, Yang, H, Haxhija, EQ, Spencer, AU, Teitelbaum, DH: Intestinal intraepithelial lymphocyte derived angiotensin converting enzyme modulates epithelial cell apoptosis.  Apoptosis 2005 10(6):1305-1315